Frequency-domain photon migration measurements of normal and malignant tissue optical properties in a human subject

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Frequency-domain photon migration measurements of normal and malignant tissue optical properties in a human subject.

A 1-GHz multifrequency, multiwavelength frequency-domain photon migration instrument is used to measure quantitatively the optical absorption (mu(a)) and effective optical scattering (mu(s) ?) of normal and malignant tissues in a human subject. Large ellipsoidal (~10-cm major axis, ~6-cm minor axes) subcutaneous malignant lesions were compared with adjacent normal sites in the abdomen and back....

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Non-invasive measurements of breast tissue optical properties using frequency-domain photon migration.

A multiwavelength, high bandwidth (1 GHz) frequency-domain photon migration (FDPM) instrument has been developed for quantitative, non-invasive measurements of tissue optical and physiological properties. The instrument produces 300 kHz to 1 GHz photon density waves (PDWs) in optically turbid media using a network analyser, an avalanche photodiode detector and four amplitude-modulated diode las...

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Sampling tissue volumes using frequency-domain photon migration.

We demonstrate the use of Monte Carlo simulations to generate photon scattering density functions (PSDFs) that represent the tissue volume sampled by steady-state and frequency-domain photon migration. We use these results to illustrate how scaling laws can be developed to determine the mean sampling depth of the multiply scattered photons detected by photon migration methods that remain valid ...

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Temperature-dependent optical properties of Intralipid measured with frequency-domain photon-migration spectroscopy.

We present the temperature dependence of absorption and reduced scattering coefficients of 1.8% Intralipid measured by frequency-domain photon-migration spectroscopy between 710 and 850 nm. These measurements were made in the physiologically relevant 30 to 40 degrees C temperature range. The temperature coefficients for absorption were consistent during heating and cooling and follow closely ot...

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ژورنال

عنوان ژورنال: Applied Optics

سال: 1997

ISSN: 0003-6935,1539-4522

DOI: 10.1364/ao.36.000010